Elective Nodal Irradiation for Non-small Cell Lung Cancer Complicated With Chronic Obstructive Pulmonary Disease Affects Immunotherapy Αfter Definitive Chemoradiotherapy.
Anticancer Res
; 40(12): 6957-6970, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-33288590
ABSTRACT
BACKGROUND/AIM:
The aim of this retrospective study was to detect the frequency, reasons, and significant factors for not receiving immunotherapy after chemoradiotherapy in non-small cell lung cancer (NSCLC) patients. PATIENTS ANDMETHODS:
Thirty-four patients with NSCLC received definitive chemoradiotherapy. The endpoint of this study was receiving durvalumab within 45 days after chemoradiotherapy for NSCLC.RESULTS:
Twenty-five of 34 (73%) patients received immunotherapy within 45 days after chemoradiotherapy. The reasons for not receiving immunotherapy were radiation pneumonitis (50%), radiation esophagitis (10%), and four other reasons (40%). Univariate analysis showed that significant factors for not receiving immunotherapy were elective nodal irradiation (ENI)+ and chronic obstructive pulmonary disease (COPD)+. The rate of immunotherapy was 100% (17/17 cases) in the COPD- and ENI- group, and 16% (1/6 cases) in the COPD+ and ENI+ group.CONCLUSION:
ENI for NSCLC complicated with COPD decreased the rate of immunotherapy after definitive chemoradiotherapy.Palavras-chave
Volumetric modulated arc therapy (VMAT); accelerated hyperfractionated thoracic radiotherapy (AHTRT); anti-programmed cell death ligand-1 immune checkpoint inhibitor (ICIs); intensity modulated radiation therapy (IMRT); involved field radiotherapy irradiation (IFR-IFI); twice-daily thoracic radiotherapy (BID-TRT)
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
/
Doença Pulmonar Obstrutiva Crônica
/
Neoplasias Pulmonares
/
Metástase Linfática
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article