Low-dose intravenous dexmedetomidine reduces shivering following cesarean delivery: a randomized controlled trial.
Int J Obstet Anesth
; 45: 49-55, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33293185
ABSTRACT
BACKGROUND:
Intravenous dexmedetomidine 30⯵g reduces shivering after cesarean delivery but can result in sedation and dry mouth. We hypothesized that prophylactic administration of 10⯵g of IV dexmedetomidine would reduce the patient-reported severity of shivering after cesarean delivery, without an increased incidence of side effects.METHODS:
After institutional review board approval and informed written consent, women undergoing scheduled cesarean delivery with spinal or combined spinal-epidural anesthesia were randomized to receive either intravenous normal saline or dexmedetomidine 10⯵g immediately after delivery. The primary outcome was a patient-rated subjective shivering score using a 10-cm visual analog scale at 30 and 60â¯min after arrival in the Post-Anesthesia Care Unit. Secondary outcomes included subjective scores for pain, nausea, itching, dry mouth, and sedation, as well as 24-h medication administration and investigator-rated observations of shivering, vomiting, pruritus, and sedation. Repeated measures ANOVA with Tukey-Kramer multiple-comparison test was applied for primary outcomes.RESULTS:
One hundred patients were enrolled, and 85 completed the study and were included in analysis. The mean⯱â¯SD shivering score in the dexmedetomidine group was significantly lower by repeated measures analysis than among controls across the first 60â¯min (P=0.0002), and individually at both 30 and 60â¯min (placebo 1.8⯱â¯2.6 vs. dexmedetomidine 0.6⯱â¯1.4 at 30â¯min; 1.2⯱â¯2.1 vs. 0.3⯱â¯0.6 at 60â¯min; both P <0.01). Patient-rated and observer-rated side effects did not significantly differ between groups.CONCLUSIONS:
Prophylactic administration of intravenous dexmedetomidine 10⯵g after delivery reduces shivering without notable side effects.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dexmedetomidina
/
Raquianestesia
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
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Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article