ß-Arrestin-Biased AT<sub>1</sub> Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.

Kashihara, Toshihide; Kawagishi, Hiroyuki; Nakada, Tsutomu; Numaga-Tomita, Takuro; Kadota, Shin; Wolf, Elena E; Du, Cheng-Kun; Shiba, Yuji; Morimoto, Sachio; Yamada, Mitsuhiko

ß-Arrestin-Biased AT₁ Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.

Kashihara, Toshihide; Kawagishi, Hiroyuki; Nakada, Tsutomu; Numaga-Tomita, Takuro; Kadota, Shin; Wolf, Elena E; Du, Cheng-Kun; Shiba, Yuji; Morimoto, Sachio; Yamada, Mitsuhiko.

Afiliação

Kashihara T; Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Kawagishi H; Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Nakada T; Department of Biotechnology, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan.
Numaga-Tomita T; Department of Instrumental Analysis, Research Center for Supports to Advanced Science, Shinshu University, Matsumoto, Japan.
Kadota S; Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Wolf EE; Department of Biotechnology, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan.
Du CK; Department of Regenerative Science and Medicine, School of Medicine, Shinshu University, Matsumoto, Japan.
Shiba Y; Division of Nephrology and Division of Vascular Endothelium and Microcirculation, Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Morimoto S; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Yamada M; Department of Biotechnology, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan.

JACC Basic Transl Sci ; 5(11): 1057-1069, 2020 Nov.

Article em En | MEDLINE | ID: mdl-33294739

Palavras-chave

AT1R, angiotensin type 1 receptor; AngII, angiotensin II; BBA, ß-arrestinbiased angiotensin type 1 receptor agonist; ECG, electrocardiography; GPCR, G proteincoupled receptor; LTCC, CaV1.2 L-type Ca2+ channel; OCR, oxygen consumption rate; PHF, pediatric heart failure; ROS, reactive oxygen species; TRV027; UCG, ultrasound cardiogram; congenital dilated cardiomyopathy; hiPSC-CM, human induced pluripotent stem cellderived cardiac myocyte; human induced pluripotent stem cell-derived cardiac myocytes; inotropic vasodilator; mNVCM, mouse neonatal ventricular cardiac myocyte; neonate; pediatric heart failure; ß-arrestinbiased AT1 angiotensin receptor agonist

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article