Amide-Linked C4â³-Saccharide Modification of KRN7000 Provides Potent Stimulation of Human Invariant NKT Cells and Anti-Tumor Immunity in a Humanized Mouse Model.

Saavedra-Avila, Noemi Alejandra; Keshipeddy, Santosh; Guberman-Pfeffer, Matthew J; Pérez-Gallegos, Ayax; Saini, Neeraj K; Schäfer, Carolina; Carreño, Leandro J; Gascón, José A; Porcelli, Steven A; Howell, Amy R

Amide-Linked C4â³-Saccharide Modification of KRN7000 Provides Potent Stimulation of Human Invariant NKT Cells and Anti-Tumor Immunity in a Humanized Mouse Model.

Saavedra-Avila, Noemi Alejandra; Keshipeddy, Santosh; Guberman-Pfeffer, Matthew J; Pérez-Gallegos, Ayax; Saini, Neeraj K; Schäfer, Carolina; Carreño, Leandro J; Gascón, José A; Porcelli, Steven A; Howell, Amy R.

Afiliação

Keshipeddy S; Department of Chemistry, The University of Connecticut, Storrs, Connecticut 06269-3060, United States.
Guberman-Pfeffer MJ; Department of Chemistry, The University of Connecticut, Storrs, Connecticut 06269-3060, United States.
Schäfer C; Millennium Institute on Immunology and Immunotherapy, Programa de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Carreño LJ; Millennium Institute on Immunology and Immunotherapy, Programa de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Gascón JA; Department of Chemistry, The University of Connecticut, Storrs, Connecticut 06269-3060, United States.
Howell AR; Department of Chemistry, The University of Connecticut, Storrs, Connecticut 06269-3060, United States.

ACS Chem Biol ; 15(12): 3176-3186, 2020 12 18.

Article em En | MEDLINE | ID: mdl-33296161

Assuntos

Amidas/química; Galactosilceramidas/química; Células Matadoras Naturais/efeitos dos fármacos; Neoplasias/imunologia; Açúcares/química; Animais; Galactosilceramidas/farmacologia; Glicolipídeos/farmacologia; Humanos; Células Matadoras Naturais/imunologia; Camundongos; Modelos Animais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Açúcares / Amidas / Galactosilceramidas / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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