Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges.
Am J Respir Cell Mol Biol
; 64(4): 416-425, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33296619
ABSTRACT
The coronavirus disease (COVID-19) pandemic is sweeping the globe. Even with a number of effective vaccines being approved and available to the public, new cases and escalating mortality are climbing every day. ACE2 (angiotensin-converting enzyme 2) is the primary receptor for the COVID-19 causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and its complexation with spike proteins plays a crucial role in viral entry into host cells and the subsequent infection. Blocking this binding event or reducing the accessibility of the virus to the ACE2 receptor, represents an alternative strategy to prevent COVID-19. In addition, the biological significance of ACE2 in modulating the innate immune system and tissue repair cascades and anchors its therapeutic potential for treating the infected patients. In this viewpoint article, we review the current efforts of exploiting ACE2 as a therapeutic target to address this dire medical need. We also provide a holistic view of the pros and cons of each treatment strategy. We highlight the fundamental and translational challenges in moving these research endeavors to clinical applications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
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Enzima de Conversão de Angiotensina 2
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SARS-CoV-2
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Tratamento Farmacológico da COVID-19
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Imunidade Inata
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article