Association of Human Papillomavirus With Oral Lichen Planus and Oral Leukoplakia: A Meta-analysis.
J Evid Based Dent Pract
; 20(4): 101485, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33303094
ABSTRACT
OBJECTIVES:
To estimate the association of human papillomavirus (HPV) infection with oral lichen planus (OLP) and oral leukoplakia (OLK), and determine risk cofactors. STUDYDESIGN:
Seven databases were searched for case-control or cross-sectional studies of OLP and OLK with healthy controls, published between 1976 and 2020. The Meta package of R software was applied to calculate the pooled odds ratios (OR) and 95% confidence interval (CI).RESULTS:
Thirty-six articles were finally included. OLP and OLK cases had a higher association with HPV infection than controls (OLP OR 4.91, 95% CI 2.76-8.72; OLK OR 2.51, 95% CI 1.55-4.07). In subgroup analyses, the OR of HPV infection was higher with erosive lesions than with nonerosive lesions (OLP OR 5.36 and 3.47, respectively; OLK OR 3.34 and 3.21, respectively). Oral lesions were more strongly associated with HPV16/18 than with HPV6/11 (OLP OR 7.84 and 1.42, respectively; OLK OR 6.05 and 1.87, respectively) and varied by geographic region (OLP OR 4.01-7.02; OLK OR 1.46-27.13).CONCLUSIONS:
Oral HPV infection, particularly infection with HPV 16/18, was strongly associated with OLP and OLK. Risk cofactors included erosive lesions and geographic region.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Líquen Plano Bucal
/
Alphapapillomavirus
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article