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The long-acting C5 inhibitor, ravulizumab, is effective and safe in pediatric patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment.
Ariceta, Gema; Dixon, Bradley P; Kim, Seong Heon; Kapur, Gaurav; Mauch, Teri; Ortiz, Stephan; Vallee, Marc; Denker, Andrew E; Kang, Hee Gyung; Greenbaum, Larry A.
Afiliação
  • Ariceta G; Paediatric Nephrology Department, University Hospital Vall d'Hebron, Barcelona, Spain. Electronic address: gariceta@vhebron.net.
  • Dixon BP; Renal Section, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Kim SH; Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.
  • Kapur G; Faculty of Pediatric Sciences, Central Michigan University, Mount Pleasant, Michigan, USA.
  • Mauch T; Division of Pediatric Nephrology, University of Nebraska Medical Center, Omaha Children's Hospital and Medical Center, Omaha, Nebraska, USA; Department of Nephrology and Hypertension, Division of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
  • Ortiz S; Clinical and Non-Clinical Pharmacology, Alexion Pharmaceuticals Inc., Boston, Massachusetts, USA.
  • Vallee M; Biostatistics, Alexion Pharmaceuticals Inc., Boston, Massachusetts, USA.
  • Denker AE; Clinical Development, Alexion Pharmaceuticals Inc., Boston, Massachusetts, USA.
  • Kang HG; Division of Pediatric Nephrology, Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Greenbaum LA; Division of Pediatric Nephrology, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Kidney Int ; 100(1): 225-237, 2021 07.
Article em En | MEDLINE | ID: mdl-33307104
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inativadores do Complemento / Microangiopatias Trombóticas / Anticorpos Monoclonais Humanizados / Síndrome Hemolítico-Urêmica Atípica Tipo de estudo: Diagnostic_studies Limite: Adolescent / Child / Child, preschool / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inativadores do Complemento / Microangiopatias Trombóticas / Anticorpos Monoclonais Humanizados / Síndrome Hemolítico-Urêmica Atípica Tipo de estudo: Diagnostic_studies Limite: Adolescent / Child / Child, preschool / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article