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Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer.
Wang, Junwei; He, Guangchao; Li, Hui; Ge, Yiran; Wang, Shuping; Xu, Yungen; Zhu, Qihua.
Afiliação
  • Wang J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • He G; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China.
  • Li H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Ge Y; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China.
  • Wang S; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China.
  • Xu Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: xyg@cpu.edu.cn.
  • Zhu Q; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: zhuqihua@vip.126.com.
Eur J Med Chem ; 213: 113054, 2021 Mar 05.
Article em En | MEDLINE | ID: mdl-33309164
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poli(ADP-Ribose) Polimerases / Fosfatidilinositol 3-Quinases / Neoplasias de Mama Triplo Negativas / Inibidores de Poli(ADP-Ribose) Polimerases / Inibidores de Fosfoinositídeo-3 Quinase / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poli(ADP-Ribose) Polimerases / Fosfatidilinositol 3-Quinases / Neoplasias de Mama Triplo Negativas / Inibidores de Poli(ADP-Ribose) Polimerases / Inibidores de Fosfoinositídeo-3 Quinase / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article