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Clinical and biological features of B-cell neoplasms with CDK6 translocations: an association with a subgroup of splenic marginal zone lymphomas displaying frequent CD5 expression, prolymphocytic cells, and TP53 abnormalities.
Gailllard, Baptiste; Cornillet-Lefebvre, Pascale; Le, Quoc-Hung; Maloum, Karim; Pannetier, Mélanie; Lecoq-Lafon, Carinne; Grange, Béatrice; Jondreville, Ludovic; Michaux, Lucienne; Nadal, Nathalie; Ittel, Antoine; Luquet, Isabelle; Struski, Stéphanie; Lefebvre, Christine; Gaillard, Jean-Baptiste; Lafage-Pochitaloff, Marina; Balducci, Estelle; Penther, Dominique; Barin, Carole; Collonge-Rame, Marie Agnès; Jimenez-Poquet, Mélanie; Richebourg, Steven; Lemaire, Pierre; Defasque, Sabine; Radford-Weiss, Isabelle; Bidet, Audrey; Susin, Santos A; Nguyen-Khac, Florence; Chapiro, Elise.
Afiliação
  • Gailllard B; Laboratoire d'Hématologie, Hôpital Robert Debré, Reims, France.
  • Cornillet-Lefebvre P; Laboratoire d'Hématologie, Hôpital Robert Debré, Reims, France.
  • Le QH; Service d'Hématologie Clinique, Hôpital Robert Debré, Reims, France.
  • Maloum K; Service d'Hématologie Biologique, Hôpital Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
  • Pannetier M; Laboratoire d'Hématologie, Centre Hospitalo-Universitaire, Rennes, France.
  • Lecoq-Lafon C; Laboratoire d'Hématologie, Hôpital Robert Debré, Reims, France.
  • Grange B; Service d'Hématologie Biologique, Hospices Civils de Lyon, Lyon, France.
  • Jondreville L; Centre de Recherche des Cordeliers, INSERM UMRS_1138, Cell Death and Drug Resistance in Lymphoproliferative Disorders Team, Paris, France.
  • Michaux L; Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium.
  • Nadal N; Service de génétique chromosomique et moléculaire, CHU Dijon, France.
  • Ittel A; Laboratoire de Cytogénétique Hématologique, CHU de Strasbourg, Strasbourg, France.
  • Luquet I; Laboratoire d'Hématologie, Institut Universitaire du Cancer de Toulouse, Toulouse, France.
  • Struski S; Laboratoire d'Hématologie, Institut Universitaire du Cancer de Toulouse, Toulouse, France.
  • Lefebvre C; Laboratoire de Cytogénétique Onco-Hématologique, CHU Grenoble, France.
  • Gaillard JB; Unité de Génétique Chromosomique, CHU Montpellier, France.
  • Lafage-Pochitaloff M; Laboratoire de Cytogénétique Onco-Hématologique, Hôpital de la Timone, AP-HM, Aix-Marseille Université, Marseille, France.
  • Balducci E; Laboratoire d'Hématologie, Hôpital Paul Brousse, APHP, Villejuif, France.
  • Penther D; Laboratoire de Génétique Oncologique, CLCC Henri Becquerel and INSERM U1245, Rouen, France.
  • Barin C; Laboratoire de Cytogénétique hématologique, Service de Génétique, CHRU Bretonneau, Tours, France.
  • Collonge-Rame MA; Cytogénétique et Génétique Moléculaire, CHU Besançon, Besançon, France.
  • Jimenez-Poquet M; Service de Génétique, Laboratoire Laborizon Centre- ABO, Chambray les Tours, France.
  • Richebourg S; Laboratoire de Cytogénétique Onco-Hématologique, CHU de Québec - Université Laval, Québec, Canada.
  • Lemaire P; Laboratoire d'Hématologie, Hôpital Saint-Louis, APHP, Paris, France.
  • Defasque S; Secteur cytogénétique hématologique, Laboratoire CERBA, Saint-Ouen l'Aumône, France.
  • Radford-Weiss I; Laboratoire de Cytogénétique, Hôpital Necker - Enfants Malades, APHP, Paris, France.
  • Bidet A; Laboratoire d'Hématologie, CHU Bordeaux-Haut Lévêque, Bordeaux, France.
  • Susin SA; Centre de Recherche des Cordeliers, INSERM UMRS_1138, Cell Death and Drug Resistance in Lymphoproliferative Disorders Team, Paris, France.
  • Nguyen-Khac F; Sorbonne Université, Paris, France.
  • Chapiro E; Service d'Hématologie Biologique, Hôpital Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
Br J Haematol ; 193(1): 72-82, 2021 04.
Article em En | MEDLINE | ID: mdl-33314017
A translocation involving the cyclin-dependent kinase 6 (CDK6) gene [t(CDK6)] is a rare but recurrent abnormality in B-cell neoplasms. To further characterise this aberration, we studied 57 cases; the largest series reported to date. Fluorescence in situ hybridisation analysis confirmed the involvement of CDK6 in all cases, including t(2;7)(p11;q21) immunoglobulin kappa locus (IGK)/CDK6 (n = 51), t(7;14)(q21;q32) CDK6/immunoglobulin heavy locus (IGH) (n = 2) and the previously undescribed t(7;14)(q21;q11) CDK6/T-cell receptor alpha locus (TRA)/T-cell receptor delta locus (TRD) (n = 4). In total, 10 patients were diagnosed with chronic lymphocytic leukaemia, monoclonal B-cell lymphocytosis or small lymphocytic lymphoma, and 47 had small B-cell lymphoma (SmBL) including 36 cases of marginal zone lymphoma (MZL; 34 splenic MZLs, one nodal MZL and one bronchus-associated lymphoid tissue lymphoma). In all, 18 of the 26 cytologically reviewed cases of MZL (69%) had an atypical aspect with prolymphocytic cells. Among the 47 patients with MZL/SmBL, CD5 expression was found in 26 (55%) and the tumour protein p53 (TP53) deletion in 22 (47%). The TP53 gene was mutated in 10/30 (33%); the 7q deletion was detected in only one case, and no Notch receptor 2 (NOTCH2) mutations were found. Immunoglobulin heavy-chain variable-region (IGHV) locus sequencing revealed that none harboured an IGHV1-02*04 gene. Overall survival was 82% at 10 years and not influenced by TP53 aberration. Our present findings suggest that most t(CDK6)+ neoplasms correspond to a particular subgroup of indolent marginal zone B-cell lymphomas with distinctive features.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esplênicas / Leucemia Linfocítica Crônica de Células B / Proteína Supressora de Tumor p53 / Linfoma de Zona Marginal Tipo Células B / Antígenos CD5 / Quinase 6 Dependente de Ciclina Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esplênicas / Leucemia Linfocítica Crônica de Células B / Proteína Supressora de Tumor p53 / Linfoma de Zona Marginal Tipo Células B / Antígenos CD5 / Quinase 6 Dependente de Ciclina Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article