Shikonin induces odontoblastic differentiation of dental pulp stem cells via AKT-mTOR signaling in the presence of CD44.

Kajiura, Kunihiro; Umemura, Naoki; Ohkoshi, Emika; Ohta, Takahisa; Kondoh, Nobuo; Kawano, Satoshi

Kajiura, Kunihiro; Umemura, Naoki; Ohkoshi, Emika; Ohta, Takahisa; Kondoh, Nobuo; Kawano, Satoshi.

Afiliação

Kajiura K; Department of Endodontics, Asahi University School of Dentistry, Gifu, Japan.
Umemura N; Department of Oral Biochemistry, Asahi University School of Dentistry, Gifu, Japan.
Ohkoshi E; Department of Natural and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Aomori University, Aomori, Japan.
Ohta T; Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry, Gifu, Japan.
Kondoh N; Department of Oral Biochemistry, Asahi University School of Dentistry, Gifu, Japan.
Kawano S; Department of Endodontics, Asahi University School of Dentistry, Gifu, Japan.

Connect Tissue Res ; 62(6): 689-697, 2021 11.

Article em En | MEDLINE | ID: mdl-33334200

Assuntos

Naftoquinonas; Odontoblastos; Diferenciação Celular; Células Cultivadas; Polpa Dentária/metabolismo; Proteínas da Matriz Extracelular/metabolismo; Ácido Hialurônico/metabolismo; Naftoquinonas/metabolismo; Naftoquinonas/farmacologia; Fosfoproteínas/genética; Fosfoproteínas/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Células-Tronco; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

CD44; Dental pulp stem cells; dentin sialophosphoprotein; mammalian target of rapamycin; odontoblast differentiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Odontoblastos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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