Addition of L-cysteine to the N- or C-terminus of the all-D-enantiomer [D(KLAKLAK)2] increases antimicrobial activities against multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli.

Ohno, Maki K; Kirikae, Teruo; Yoshihara, Eisaku; Kirikae, Fumiko; Ishida, Isao

Addition of L-cysteine to the N- or C-terminus of the all-D-enantiomer [_D(KLAKLAK)₂] increases antimicrobial activities against multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli.

Ohno, Maki K; Kirikae, Teruo; Yoshihara, Eisaku; Kirikae, Fumiko; Ishida, Isao.

Afiliação

Ohno MK; Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
Kirikae T; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan.
Yoshihara E; Tokai University School of Medicine, Kanagawa, Japan.
Kirikae F; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan.
Ishida I; Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.

PeerJ ; 8: e10176, 2020.

Article em En | MEDLINE | ID: mdl-33335804

Palavras-chave

Antimicrobial peptide; Multidrug-resistant Gram-negative bacteria

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article