Adherence to and effectiveness of lenalidomide after 1 year of treatment in a real world setting.
J Oncol Pharm Pract
; 28(1): 24-30, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-33349148
ABSTRACT
BACKGROUND:
In combination with dexamethasone, lenalidomide is prescribed in the oral treatment of Multiple Myeloma for patients who have received at least one previous therapy.OBJECTIVE:
The objective of this study is to evaluate medication adherence to lenalidomide of Multiple Myeloma patients, as well as Progression Free Survival and Overall Survival one year from the beginning of the treatment.SETTING:
The study was carried out in Pescara Hospital, in Italy. All Multiple Myeloma patients who began lenalidomide therapy between January 1, 2012 and June 30, 2016 were included in our study.METHODS:
Adherence to treatment was calculated by using the ratio between the Received Daily Dose and the Prescribed Daily Dose. Effectiveness in real world has been evaluated as Progression Free Survival and Overall Survival one year from the beginning of the treatment.Main outcomesmeasure:
We assessed medication adherence and effectiveness of lenalidomide in the treatment of Multiple Myeloma.RESULTS:
Adherence to the overall mean treatment was 0.73 ± 0.15, relative to 81 patients evaluated in our study. 32% of patients achieved an adherence equal to or greater than 80%. Real-life effectiveness in terms of Progression Free Survival and Overall Survival showed values of ââ53.75% and 88%, respectively, one year from the beginning of treatment.CONCLUSION:
The analysis of adherence in Multiple Myeloma patients treated with lenalidomide one year from the beginning of therapy reveal a concerning lack of adherence. Moreover, the lack of correlation of the levels of adherence with patient-related variables shows that, in the case of Multiple Myeloma, adherence is not related to personal, social and environmental characteristics that may determine each patient's correct treatment implementation, but is directly influenced by disease evolution.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dexametasona
/
Mieloma Múltiplo
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article