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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.
Tothova, Zuzana; Valton, Anne-Laure; Gorelov, Rebecca A; Vallurupalli, Mounica; Krill-Burger, John M; Holmes, Amie; Landers, Catherine C; Haydu, J Erika; Malolepsza, Edyta; Hartigan, Christina; Donahue, Melanie; Popova, Katerina D; Koochaki, Sebastian; Venev, Sergey V; Rivera, Jeanne; Chen, Edwin; Lage, Kasper; Schenone, Monica; D'Andrea, Alan D; Carr, Steven A; Morgan, Elizabeth A; Dekker, Job; Ebert, Benjamin L.
Afiliação
  • Tothova Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Valton AL; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Gorelov RA; Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Vallurupalli M; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Krill-Burger JM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Holmes A; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Landers CC; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Haydu JE; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Malolepsza E; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Hartigan C; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Donahue M; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Popova KD; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Koochaki S; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Venev SV; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Rivera J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Chen E; Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Lage K; Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
  • Schenone M; Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
  • D'Andrea AD; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Carr SA; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Morgan EA; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Dekker J; Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
  • Ebert BL; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
JCI Insight ; 6(3)2021 02 08.
Article em En | MEDLINE | ID: mdl-33351783
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Proteínas Cromossômicas não Histona / Leucemia Mieloide Aguda / Proteínas de Ciclo Celular / Reparo do DNA / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Proteínas Cromossômicas não Histona / Leucemia Mieloide Aguda / Proteínas de Ciclo Celular / Reparo do DNA / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article