TCR Transgenic Mice: A Valuable Tool for Studying Viral Immunopathogenesis Mechanisms.
Int J Mol Sci
; 21(24)2020 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-33353154
ABSTRACT
Viral infectious diseases are a significant burden on public health and the global economy, and new viral threats emerge continuously. Since CD4+ and CD8+ T cell responses are essential to eliminating viruses, it is important to understand the underlying mechanisms of anti-viral T cell-mediated immunopathogenesis during viral infections. Remarkable progress in transgenic (Tg) techniques has enabled scientists to more readily understand the mechanisms of viral pathogenesis. T cell receptor (TCR) Tg mice are extremely useful in studying T cell-mediated immune responses because the majority of T cells in these mice express specific TCRs for partner antigens. In this review, we discuss the important studies utilizing TCR Tg mice to unveil underlying mechanisms of T cell-mediated immunopathogenesis during viral infections.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus
/
Viroses
/
Receptores de Antígenos de Linfócitos T
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article