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Model-based comparison of organ at risk protection between VMAT and robustly optimised IMPT plans.
Behrends, Carina; Haussmann, Jan; Kramer, P-H; Langendijk, Johannes A; Gottschlag, Holger; Geismar, Dirk; Budach, Wilfried; Timmermann, Beate.
Afiliação
  • Behrends C; West German Proton Therapy Centre Essen (WPE), Essen, Germany; Heinrich-Heine-University, Düsseldorf, Germany; West German Cancer Centre (WTZ), Essen, Germany. Electronic address: carina.behrends@uk-essen.de.
  • Haussmann J; Department of Radiation Oncology, Heinrich-Heine-University, Düsseldorf, Germany.
  • Kramer PH; West German Proton Therapy Centre Essen (WPE), Essen, Germany; West German Cancer Centre (WTZ), Essen, Germany.
  • Langendijk JA; Department of Radiation Oncology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
  • Gottschlag H; Department of Radiation Oncology, Heinrich-Heine-University, Düsseldorf, Germany.
  • Geismar D; West German Proton Therapy Centre Essen (WPE), Essen, Germany; Department of Particle Therapy, University Hospital Essen, Essen, Germany.
  • Budach W; Department of Radiation Oncology, Heinrich-Heine-University, Düsseldorf, Germany.
  • Timmermann B; West German Proton Therapy Centre Essen (WPE), Essen, Germany; West German Cancer Centre (WTZ), Essen, Germany; Department of Particle Therapy, University Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Germany.
Z Med Phys ; 31(1): 5-15, 2021 Feb.
Article em De | MEDLINE | ID: mdl-33358063
ABSTRACT
The comparison between intensity-modulated proton therapy (IMPT) and volume-modulated arc therapy (VMAT) plans, based on models of normal tissue complication probabilities (NTCP), can support the choice of radiation modality. IMPT irradiation plans for 50 patients with head and neck tumours originally treated with photon therapy have been robustly optimised against density and setup uncertainties. The dose distribution has been calculated with a Monte Carlo (MC) algorithm. The comparison of the plans was based on dose-volume parameters in organs at risk (OARs) and NTCP-calculations for xerostomia, sticky saliva, dysphagia and tube feeding using Langendijk's model-based approach. While the dose distribution in the target volumes is similar, the IMPT plans show better protection of OARs. Therefore, it is not the high dose confirmation that constitutes the advantage of protons, but it is the reduction of the mid-to-low dose levels compared to photons. This work investigates to what extent the advantages of proton radiation are beneficial for the patient's post-therapeutic quality of life (QoL). As a result, approximately one third of the patients examined benefit significantly from proton therapy with regard to possible late side effects. Clinical data is needed to confirm the model-based calculations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioterapia de Intensidade Modulada / Órgãos em Risco / Modelos Teóricos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: De Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioterapia de Intensidade Modulada / Órgãos em Risco / Modelos Teóricos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: De Ano de publicação: 2021 Tipo de documento: Article