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Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity.
Mackwitz, Marcel K W; Hesping, Eva; Eribez, Korina; Schöler, Andrea; Antonova-Koch, Yevgeniya; Held, Jana; Winzeler, Elizabeth A; Andrews, Katherine T; Hansen, Finn K.
Afiliação
  • Mackwitz MKW; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany.
  • Hesping E; Griffith Institute for Drug Discovery, 46 Don Young Road, Nathan Campus, Griffith University, QLD, 4111, Australia.
  • Eribez K; Department of Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Drive 0741, La Jolla, CA, 92093, United States.
  • Schöler A; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany.
  • Antonova-Koch Y; Department of Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Drive 0741, La Jolla, CA, 92093, United States.
  • Held J; Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Wilhelmstr. 27, 72074, Tübingen, Germany.
  • Winzeler EA; Department of Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Drive 0741, La Jolla, CA, 92093, United States.
  • Andrews KT; Griffith Institute for Drug Discovery, 46 Don Young Road, Nathan Campus, Griffith University, QLD, 4111, Australia. Electronic address: k.andrews@griffith.edu.au.
  • Hansen FK; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany; Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany. Electronic address: finn.hansen@uni-bonn.de.
Eur J Med Chem ; 211: 113065, 2021 Feb 05.
Article em En | MEDLINE | ID: mdl-33360801
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Inibidores de Histona Desacetilases / Antimaláricos Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Inibidores de Histona Desacetilases / Antimaláricos Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article