Liquid-holding experiments with human lymphocytes. III. Experiments with G0 and G1 cells.
Mutat Res
; 207(1): 41-4, 1988 Jan.
Article
em En
| MEDLINE
| ID: mdl-3336378
ABSTRACT
Liquid holding (LH) experiments were performed with human peripheral lymphocytes treated in the G0 (G0-LH) or the G1 (G1-LH) phase of the cell cycle with diepoxybutane (DEB) or methylnitrosourea (MNU). In the G0-LH system, treatment with DEB but not with MNU led to a lowering of the frequencies of sister-chromatid exchanges (SCE). In the G1-LH system treatment with both chemicals led to a lowering of the SCE frequencies during the LH. These results are concluded to mean that lesions induced by DEB but not by MNU can be repaired in G0 cells and that G1 cells can repair both DEB and MNU induced lesions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Troca de Cromátide Irmã
/
Linfócitos
/
Compostos de Epóxi
/
Éteres Cíclicos
/
Interfase
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Metilnitrosoureia
/
Mutação
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article