Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation.

Evans, Stephanie; Butler, J Russell; Mattila, Joshua T; Kirschner, Denise E

Evans, Stephanie; Butler, J Russell; Mattila, Joshua T; Kirschner, Denise E.

Afiliação

Evans S; Microbiology and Immunology, School of Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Butler JR; Division of Biological Sciences, Advent Health University, Orlando, Florida, United States of America.
Mattila JT; Department of Infectious Disease and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, United States of America.
Kirschner DE; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

PLoS Comput Biol ; 16(12): e1008520, 2020 12.

Article em En | MEDLINE | ID: mdl-33370784

Assuntos

Granuloma/patologia; Macrófagos/patologia; Miofibroblastos/patologia; Biologia de Sistemas; Tuberculose/patologia; Fibrose; Humanos; Mycobacterium tuberculosis/imunologia; Fator de Transcrição STAT1/metabolismo; Fator de Transcrição STAT3/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Biologia de Sistemas / Miofibroblastos / Granuloma / Macrófagos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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