PLK1 Induces Chromosomal Instability and Overrides Cell-Cycle Checkpoints to Drive Tumorigenesis.

Gheghiani, Lilia; Wang, Lei; Zhang, Youwei; Moore, Xavier T R; Zhang, Jinglei; Smith, Steven C; Tian, Yijun; Wang, Liang; Turner, Kristi; Jackson-Cook, Colleen K; Mukhopadhyay, Nitai D; Fu, Zheng

Gheghiani, Lilia; Wang, Lei; Zhang, Youwei; Moore, Xavier T R; Zhang, Jinglei; Smith, Steven C; Tian, Yijun; Wang, Liang; Turner, Kristi; Jackson-Cook, Colleen K; Mukhopadhyay, Nitai D; Fu, Zheng.

Afiliação

Gheghiani L; Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.
Wang L; Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.
Zhang Y; Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.
Moore XTR; Department of Biology, Virginia Commonwealth University, Richmond, Virginia.
Zhang J; Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.
Smith SC; Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.
Tian Y; Department of Tumor Biology, Moffitt Cancer Center, University of South Florida, Tampa, Florida.
Wang L; Department of Tumor Biology, Moffitt Cancer Center, University of South Florida, Tampa, Florida.
Turner K; Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.
Jackson-Cook CK; Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.
Mukhopadhyay ND; Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.
Fu Z; Department of Biostatistics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.

Cancer Res ; 81(5): 1293-1307, 2021 03 01.

Article em En | MEDLINE | ID: mdl-33376114

Assuntos

Pontos de Checagem do Ciclo Celular/genética; Proteínas de Ciclo Celular/genética; Transformação Celular Neoplásica/genética; Instabilidade Cromossômica; Neoplasias/genética; Proteínas Serina-Treonina Quinases/genética; Proteínas Proto-Oncogênicas/genética; Animais; Proteínas de Ciclo Celular/metabolismo; Proliferação de Células/genética; Feminino; Dosagem de Genes; Regulação Neoplásica da Expressão Gênica; Humanos; Masculino; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Neoplasias/mortalidade; Prognóstico; Proteínas Serina-Treonina Quinases/metabolismo; Proto-Oncogene Mas; Proteínas Proto-Oncogênicas/metabolismo; Quinase 1 Polo-Like

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Instabilidade Cromossômica / Pontos de Checagem do Ciclo Celular / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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