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ß-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response.
de B Oliveira, Ana L; Navegantes-Lima, Kely C; Monteiro, Valter V S; Quadros, Lucas B G; de Oliveira, Juliana P; Dos Santos, Sávio M; de A Pontes, Anna C A; Dorneles, Gilson P; Romão, Pedro R T; Júnior, Luiz C R; de Oliveira, Alaíde B; Monteiro, Marta C.
Afiliação
  • de B Oliveira AL; Neuroscience and Cellular Biology Post-Graduation Program, Biology Science Institute, Federal University of Pará/UFPA, Belém 66075-900, Brazil.
  • Navegantes-Lima KC; Neuroscience and Cellular Biology Post-Graduation Program, Biology Science Institute, Federal University of Pará/UFPA, Belém 66075-900, Brazil.
  • Monteiro VVS; Center of Research of Inflammatory Diseases, Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14055230, Brazil.
  • Quadros LBG; School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, Belém 66075-900, Brazil.
  • de Oliveira JP; School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, Belém 66075-900, Brazil.
  • Dos Santos SM; Pharmaceutical Sciences Post-Graduation Program, Institute of Health Sciences, Federal University of Pará/UFPA, Belém 66075-900, Brazil.
  • de A Pontes ACA; Pharmaceutical Sciences Post-Graduation Program, Institute of Health Sciences, Federal University of Pará/UFPA, Belém 66075-900, Brazil.
  • Dorneles GP; Laboratory of Cellular and Molecular Immunology, Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, Brazil.
  • Romão PRT; Laboratory of Cellular and Molecular Immunology, Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, Brazil.
  • Júnior LCR; Laboratory of Cellular and Molecular Immunology, Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, Brazil.
  • de Oliveira AB; Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
  • Monteiro MC; Neuroscience and Cellular Biology Post-Graduation Program, Biology Science Institute, Federal University of Pará/UFPA, Belém 66075-900, Brazil.
Oxid Med Cell Longev ; 2020: 8820651, 2020.
Article em En | MEDLINE | ID: mdl-33381269
Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase. Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies. ß-Lapachone (ß-Lap) is a natural compound obtained from Tabebuia avellanedae Lorentz ex Griseb. with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity. Thus, the aim of this study was to evaluate the effects of ß-Lap in a mouse sepsis model. To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis. First, we found that in pretreated animals, ß-Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival. Moreover, ß-Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals. In the model of severe sepsis, the posttreatment with ß-Lap was able to increase the survival of animals and maintain the antioxidant defense function. In conclusion, the ß-Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Sepse Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Sepse Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article