Cannabinoids in the Management of Acute Pain: A Systematic Review and Meta-analysis.
Cannabis Cannabinoid Res
; 5(4): 290-297, 2020.
Article
em En
| MEDLINE
| ID: mdl-33381643
ABSTRACT
Objective:
To synthesize the best evidence surrounding the efficacy of cannabinoids for acute pain in the clinical setting based on subjective pain scores and observed adverse effects.Design:
Systematic review with meta-analysis. Data Sources PubMed, Embase, Cochrane Databases, and Google Scholar. Eligibility Criteria English-language randomized-controlled clinical trials comparing cannabinoids with placebo in patients with acute pain. Data Extraction andSynthesis:
Study quality was assessed using the Cochrane risk of bias tool. All stages were conducted independently by a team of three reviewers. Data were pooled through meta-analysis and stratified by route of administration. Primary Outcomes andMeasures:
Patient-reported pain and adverse events (AEs).Results:
Six trials (678 participants) were included examining oral (5 trials) and intramuscular (1 trial) cannabinoids. Overall, there was a small but statistically significant treatment effect favoring the use of cannabinoids over placebo (-0.90, 95% confidence interval [CI] -1.69 to -0.1, i 2=65%, p=0.03). When stratified by route of administration, intramuscular cannabinoids were found to have a significant reduction in pain relative to placebo (-2.98, 95% CI -4.09 to -1.87, i 2=0%, p<0.0001). No difference in effect was observed between oral cannabinoids and placebo (-0.21, 95% CI -0.64 to 0.22, i 2=3%, p=0.34). Serious AEs were rare, and similar across the cannabinoid (14/374, 3.7%) and placebo groups (8/304, 2.6%).Conclusions:
There is low-quality evidence indicating that cannabinoids may be a safe alternative for a small but significant reduction in subjective pain score when treating acute pain, with intramuscular administration resulting in a greater reduction relative to oral. Higher quality, long-term randomized-controlled trials examining whether there may be a role for cannabinoids in treating acute pain are required.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Systematic_reviews
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article