Enhanced neprilysin-mediated degradation of hippocampal Aß42 with a somatostatin peptide that enters the brain.

Rofo, Fadi; Ugur Yilmaz, Canan; Metzendorf, Nicole; Gustavsson, Tobias; Beretta, Chiara; Erlandsson, Anna; Sehlin, Dag; Syvänen, Stina; Nilsson, Per; Hultqvist, Greta

Rofo, Fadi; Ugur Yilmaz, Canan; Metzendorf, Nicole; Gustavsson, Tobias; Beretta, Chiara; Erlandsson, Anna; Sehlin, Dag; Syvänen, Stina; Nilsson, Per; Hultqvist, Greta.

Afiliação

Rofo F; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Ugur Yilmaz C; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Metzendorf N; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Gustavsson T; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Beretta C; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Erlandsson A; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Sehlin D; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Syvänen S; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Nilsson P; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Hultqvist G; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

Theranostics ; 11(2): 789-804, 2021.

Article em En | MEDLINE | ID: mdl-33391505

Assuntos

Doença de Alzheimer/tratamento farmacológico; Peptídeos beta-Amiloides/metabolismo; Barreira Hematoencefálica/efeitos dos fármacos; Encéfalo/efeitos dos fármacos; Hipocampo/metabolismo; Neprilisina/farmacologia; Fragmentos de Peptídeos/metabolismo; Somatostatina/farmacologia; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Animais; Barreira Hematoencefálica/metabolismo; Encéfalo/metabolismo; Feminino; Hormônios/farmacologia; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos

Palavras-chave

Amyloid-ß (Aß) / blood-brain barrier (BBB) / neprilysin / somatostatin (SST) / transferrin receptor (TfR)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Encéfalo / Somatostatina / Barreira Hematoencefálica / Neprilisina / Peptídeos beta-Amiloides / Doença de Alzheimer / Hipocampo Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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