Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1.

Cotton, Adam D; Nguyen, Duy P; Gramespacher, Josef A; Seiple, Ian B; Wells, James A

Cotton, Adam D; Nguyen, Duy P; Gramespacher, Josef A; Seiple, Ian B; Wells, James A.

Afiliação

Cotton AD; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States.
Nguyen DP; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States.
Gramespacher JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States.
Seiple IB; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States.
Wells JA; Cardiovascular Research Institute, University of California, San Francisco, California 94143, United States.

J Am Chem Soc ; 143(2): 593-598, 2021 01 20.

Article em En | MEDLINE | ID: mdl-33395526

Assuntos

Anticorpos/imunologia; Antígeno B7-H1/imunologia; Anticorpos/química; Antígeno B7-H1/química; Humanos; Proteólise

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígeno B7-H1 / Anticorpos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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