Overexpression of GLUT3 promotes metastasis of triple-negative breast cancer by modulating the inflammatory tumor microenvironment.

Tsai, Tai-Hua; Yang, Ching-Chieh; Kou, Tai-Chih; Yang, Chang-En; Dai, Jia-Zih; Chen, Chia-Ling; Lin, Cheng-Wei

Tsai, Tai-Hua; Yang, Ching-Chieh; Kou, Tai-Chih; Yang, Chang-En; Dai, Jia-Zih; Chen, Chia-Ling; Lin, Cheng-Wei.

Afiliação

Tsai TH; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yang CC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Kou TC; Department of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan.
Yang CE; Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.
Dai JZ; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chen CL; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Lin CW; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

J Cell Physiol ; 236(6): 4669-4680, 2021 06.

Article em En | MEDLINE | ID: mdl-33421130

Assuntos

Movimento Celular; Transportador de Glucose Tipo 3/metabolismo; Glicólise; Interleucina-8/metabolismo; Neoplasias de Mama Triplo Negativas/metabolismo; Microambiente Tumoral; Macrófagos Associados a Tumor/metabolismo; Animais; Técnicas de Cocultura; Transição Epitelial-Mesenquimal; Feminino; Regulação Neoplásica da Expressão Gênica; Transportador de Glucose Tipo 3/genética; Humanos; Interleucina-8/genética; Células MCF-7; Camundongos Endogâmicos BALB C; Camundongos Nus; Invasividade Neoplásica; Metástase Neoplásica; Células THP-1; Neoplasias de Mama Triplo Negativas/genética; Neoplasias de Mama Triplo Negativas/imunologia; Neoplasias de Mama Triplo Negativas/patologia; Macrófagos Associados a Tumor/imunologia; Regulação para Cima; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

glycolysis; inflammation; triple-negative breast cancer; tumor microenvironment; tumor-associated macrophage

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Movimento Celular / Interleucina-8 / Transportador de Glucose Tipo 3 / Microambiente Tumoral / Neoplasias de Mama Triplo Negativas / Macrófagos Associados a Tumor / Glicólise Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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