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Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box.
Reader, Janette; van der Watt, Mariëtte E; Taylor, Dale; Le Manach, Claire; Mittal, Nimisha; Ottilie, Sabine; Theron, Anjo; Moyo, Phanankosi; Erlank, Erica; Nardini, Luisa; Venter, Nelius; Lauterbach, Sonja; Bezuidenhout, Belinda; Horatscheck, Andre; van Heerden, Ashleigh; Spillman, Natalie J; Cowell, Anne N; Connacher, Jessica; Opperman, Daniel; Orchard, Lindsey M; Llinás, Manuel; Istvan, Eva S; Goldberg, Daniel E; Boyle, Grant A; Calvo, David; Mancama, Dalu; Coetzer, Theresa L; Winzeler, Elizabeth A; Duffy, James; Koekemoer, Lizette L; Basarab, Gregory; Chibale, Kelly; Birkholtz, Lyn-Marié.
Afiliação
  • Reader J; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
  • van der Watt ME; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
  • Taylor D; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town, 7701, South Africa.
  • Le Manach C; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town, 7701, South Africa.
  • Mittal N; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093-076, USA.
  • Ottilie S; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093-076, USA.
  • Theron A; Next Generation Health, Council for Scientific and Industrial Research, Pretoria, 0001, South Africa.
  • Moyo P; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
  • Erlank E; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, and Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, 2193, South Africa.
  • Nardini L; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, and Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, 2193, South Africa.
  • Venter N; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, and Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, 2193, South Africa.
  • Lauterbach S; Department of Molecular Medicine and Hematology, Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.
  • Bezuidenhout B; Department of Molecular Medicine and Hematology, Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.
  • Horatscheck A; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town, 7701, South Africa.
  • van Heerden A; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
  • Spillman NJ; Division of Infectious Diseases, Department of Medicine, Washington University, St. Louis, MO, 63110, USA.
  • Cowell AN; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093-076, USA.
  • Connacher J; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
  • Opperman D; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
  • Orchard LM; Department of Biochemistry & Molecular Biology and the Huck Centre for Malaria Research, Pennsylvania State University, University Park, PA, 16802, USA.
  • Llinás M; Department of Biochemistry & Molecular Biology and the Huck Centre for Malaria Research, Pennsylvania State University, University Park, PA, 16802, USA.
  • Istvan ES; Department of Chemistry, Pennsylvania State University, University Park, PA, 16802, USA.
  • Goldberg DE; Division of Infectious Diseases, Department of Medicine, Washington University, St. Louis, MO, 63110, USA.
  • Boyle GA; Division of Infectious Diseases, Department of Medicine, Washington University, St. Louis, MO, 63110, USA.
  • Calvo D; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town, 7701, South Africa.
  • Mancama D; Global Health Incubator Unit, GlaxoSmithKline (GSK), Severo Ochoa, 2, 28760, Tres Cantos, Madrid, Spain.
  • Coetzer TL; Next Generation Health, Council for Scientific and Industrial Research, Pretoria, 0001, South Africa.
  • Winzeler EA; Department of Molecular Medicine and Hematology, Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.
  • Duffy J; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093-076, USA.
  • Koekemoer LL; Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215, Geneva, Switzerland.
  • Basarab G; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, and Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, 2193, South Africa.
  • Chibale K; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town, 7701, South Africa.
  • Birkholtz LM; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town, 7701, South Africa.
Nat Commun ; 12(1): 269, 2021 01 11.
Article em En | MEDLINE | ID: mdl-33431834
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Pandemias / Malária / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Pandemias / Malária / Antimaláricos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article