Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series.
Clin Nucl Med
; 46(7): 605-608, 2021 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-33443955
ABSTRACT
ABSTRACT Early, accurate diagnosis of Alzheimer disease (AD) is essential but remains challenging. Neuropathological hallmarks of AD are ß-amyloid neuritic plaques and tau protein neurofibrillary tangles. 18F-Florbetapir is one of several available PET tracers for imaging cortical fibrillary ß-amyloid plaques. 18F-Flortaucipir PET was recently approved for evaluating the distribution and density of aggregated neurofibrillary tangles. We present cases of mild cognitive impairment or suspected AD to depict the nuances of flortaucipir distribution and scan interpretation as well as how combined information from amyloid and tau PET may help with differential diagnosis and prognosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbolinas
/
Tomografia por Emissão de Pósitrons
/
Etilenoglicóis
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Doença de Alzheimer
/
Compostos de Anilina
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Humans
/
Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article