Seeding Propensity and Characteristics of Pathogenic &#945;Syn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease.

Fenyi, Alexis; Duyckaerts, Charles; Bousset, Luc; Braak, Heiko; Del Tredici, Kelly; Melki, Ronald

Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease.

Fenyi, Alexis; Duyckaerts, Charles; Bousset, Luc; Braak, Heiko; Del Tredici, Kelly; Melki, Ronald.

Afiliação

Fenyi A; Institute Francois Jacob (MIRCen), CEA and Laboratory of Neurodegenerative Diseases, CNRS, 92265 Fontenay-Aux-Roses CEDEX, France.
Duyckaerts C; Laboratoire de Neuropathologie Escourolle, Hôpital de la Salpêtrière, AP-HP, & Alzheimer Prion Team, ICM, 47 Bd de l'Hôpital, 75651 CEDEX 13 Paris, France.
Bousset L; Institute Francois Jacob (MIRCen), CEA and Laboratory of Neurodegenerative Diseases, CNRS, 92265 Fontenay-Aux-Roses CEDEX, France.
Braak H; Clinical Neuroanatomy Section/Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstraße 8/1, 89081 Ulm, Germany.
Del Tredici K; Clinical Neuroanatomy Section/Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstraße 8/1, 89081 Ulm, Germany.
Melki R; Institute Francois Jacob (MIRCen), CEA and Laboratory of Neurodegenerative Diseases, CNRS, 92265 Fontenay-Aux-Roses CEDEX, France.

Cells ; 10(1)2021 01 12.

Article em En | MEDLINE | ID: mdl-33445653

Assuntos

Tronco Encefálico/patologia; Sistema Nervoso Entérico/patologia; Bulbo Olfatório/patologia; Doença de Parkinson/patologia; Fixação de Tecidos; alfa-Sinucleína/metabolismo; Adulto; Idoso; Idoso de 80 Anos ou mais; Feminino; Formaldeído; Humanos; Doença por Corpos de Lewy/patologia; Masculino; Pessoa de Meia-Idade; Neuritos/metabolismo; Neuritos/patologia; Dobramento de Proteína; Proteólise; alfa-Sinucleína/ultraestrutura

Palavras-chave

Lewy body disease; Parkinson's disease; alpha-synuclein; enteric nervous system; incidental Lewy body disease; prion-like; protein misfolding cyclic amplification (PMCA); synuclein strains; synucleinopathy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bulbo Olfatório / Doença de Parkinson / Tronco Encefálico / Fixação de Tecidos / Sistema Nervoso Entérico / Alfa-Sinucleína Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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