Physical 'strength' of the multi-protein chain connecting immune cells: Does the weakest link limit antibody affinity maturation?: The weakest link in the multi-protein chain facilitating antigen acquisition by B cells in germinal centres limits antibody affinity maturation.

Desikan, Rajat; Antia, Rustom; Dixit, Narendra M

Desikan, Rajat; Antia, Rustom; Dixit, Narendra M.

Afiliação

Desikan R; Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India.
Antia R; Department of Biology, Emory University, Atlanta, Georgia, USA.
Dixit NM; Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India.

Bioessays ; 43(4): e2000159, 2021 04.

Article em En | MEDLINE | ID: mdl-33448042

Assuntos

Linfócitos B; Centro Germinativo; Afinidade de Anticorpos; Antígenos; Proteínas

Palavras-chave

B cell; Bell model; affinity ceiling; antibody affinity maturation; evolution; follicular dendritic cell; germinal centre; humoral immunity; rupture force; vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Centro Germinativo Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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