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Squamous Cell Carcinoma of the Tongue in Young Patients: A Case Series and Literature Review.
Best, David L; Spresser, Wyatt; Shivers, Paul; Edwards, Sean P; Ward, Brent B.
Afiliação
  • Best DL; Resident, Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI. Electronic address: dlbest@med.umich.edu.
  • Spresser W; Dental Student, University of Michigan School of Dentistry, Ann Arbor, MI.
  • Shivers P; Head and Neck Oncology/Microvascular Surgery Fellow, Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI.
  • Edwards SP; James Hayward Endowed Clinical Professor of Oral and Maxillofacial Surgery, Chief of Pediatric Oral and Maxillofacial Surgery, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI.
  • Ward BB; Section Head, Chair, and Associate Professor, Department of Oral and Maxillofacial Surgery Director, Microvascular Surgery/Oncology Fellowship, University of Michigan, Ann Arbor, MI.
J Oral Maxillofac Surg ; 79(6): 1270-1286, 2021 06.
Article em En | MEDLINE | ID: mdl-33450194
PURPOSE: The purpose of this study was to describe 3 cases of tongue cancer in patients less than 21 years of age. Secondarily, a literature review was performed to examine disease presentation, risk factors, prognosis, and treatment strategies for young persons with tongue cancer. METHODS: The authors presented 3 cases of childhood tongue cancer between 2009 and 2020 at the University of Michigan Department of Oral and Maxillofacial Surgery (Ann Arbor, MI). An electronic literature review was conducted via PubMed, Embase, Web of Science, and MLibrary. RESULTS: Including the present case series, 64 studies reporting 108 cases were identified. Age at presentation ranged from newborn to 20 years, with a mean age of 14.5 years. The majority of patients were female (52.2%); 68.1% of patients presented with T1 or T2 disease. Nodal metastases were seen in 56.1% of patients. The most commonly identified predisposing factors included Fanconi anemia (13.9%), bone marrow transplant (9.3%), tobacco use (6.5%), and xeroderma pigmentosum (4.6%). Most patients received surgery alone (37.5%), followed by surgery with adjuvant radiation (33.8%); 60.6% underwent neck dissection. Overall survival was 60.3% at 1 year and 43.6% at 5 years. CONCLUSIONS: Oral tongue cancer in the young is a rare disease with poorly understood etiology. There is a need for oncologists and maxillofacial surgeons to collaborate in the study of genetic, social, environmental, and medical risk factors contributing to the disease. All patients should undergo high-throughput genetic sequencing to expand our understanding of the disease process and allow for targeted treatment strategies.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Neoplasias da Língua / Carcinoma de Células Escamosas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Adult / Female / Humans / Male / Newborn Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Neoplasias da Língua / Carcinoma de Células Escamosas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Adult / Female / Humans / Male / Newborn Idioma: En Ano de publicação: 2021 Tipo de documento: Article