Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-&#954;B signaling and NLRP3 inflammasome activation.

Qin, Weiwei; Tong, Xiyang; Liang, Rongyao; Tang, Kai; Wu, Xingdong; Jia, Yuning; Tan, Ninghua

Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.

Qin, Weiwei; Tong, Xiyang; Liang, Rongyao; Tang, Kai; Wu, Xingdong; Jia, Yuning; Tan, Ninghua.

Afiliação

Qin W; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: wqin_cpu@163.com.
Tong X; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: 1722020483@stu.cpu.edu.cn.
Liang R; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: liangrongyao114@stu.cpu.edu.cn.
Tang K; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: 3219020490@stu.cpu.edu.cn.
Wu X; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: xdw_1025@sina.com.
Jia Y; Yangtze River Pharmaceutical Group Beijing Haiyan Pharmaceutical Co., Ltd., Beijing, 102206, PR China; Beijing University of Chemical Technology, Beijing, 100029, PR China. Electronic address: jiayuning@yangzijiang.com.
Tan N; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: nhtan@cpu.edu.cn.

J Ethnopharmacol ; 271: 113827, 2021 May 10.

Article em En | MEDLINE | ID: mdl-33460751

Assuntos

Anti-Inflamatórios/farmacologia; Medicamentos de Ervas Chinesas/farmacologia; Inflamassomos/antagonistas & inibidores; Inflamação/tratamento farmacológico; Mitocôndrias/metabolismo; NF-kappa B/antagonistas & inibidores; Proteína 3 que Contém Domínio de Pirina da Família NLR/antagonistas & inibidores; Animais; Anti-Inflamatórios/uso terapêutico; Proteínas de Transporte/metabolismo; Citocinas/antagonistas & inibidores; Citocinas/sangue; Modelos Animais de Doenças; Medicamentos de Ervas Chinesas/uso terapêutico; Dinaminas/antagonistas & inibidores; Homeostase/efeitos dos fármacos; Humanos; Inflamação/metabolismo; Lesão Pulmonar/induzido quimicamente; Lesão Pulmonar/prevenção & controle; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Masculino; Metaloproteinase 9 da Matriz/genética; Metaloproteinase 9 da Matriz/metabolismo; Camundongos Endogâmicos C57BL; Mitocôndrias/efeitos dos fármacos; Dinâmica Mitocondrial/efeitos dos fármacos; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Sepse/induzido quimicamente; Sepse/tratamento farmacológico; Transdução de Sinais/efeitos dos fármacos; Células THP-1; Tiorredoxinas/metabolismo; Fator de Transcrição RelA/metabolismo

Palavras-chave

3-Methyladenine; Adenosine triphosphate; Cyclosporin A; Drp1; Lipopolysaccharide; Lung injury; Mdivi-1; Mitochondrial homeostasis; Monosodium urate; N-acetylcysteine; NF-κB signaling; NLRP3 inflammasome; Phorbol-12-myristate-13-acetate; PubChem CID: 11970143; PubChem CID: 12035; PubChem CID: 135398661; PubChem CID: 23697816; PubChem CID: 27924; PubChem CID: 3825829; PubChem CID: 5284373; PubChem CID: 5957; Suhuang antitussive capsule

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / NF-kappa B / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Inflamação / Anti-Inflamatórios / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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