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Daptomycin Resistance in Enterococcus faecium Can Be Delayed by Disruption of the LiaFSR Stress Response Pathway.
Prater, Amy G; Mehta, Heer H; Beabout, Kathryn; Supandy, Adeline; Miller, William R; Tran, Truc T; Arias, Cesar A; Shamoo, Yousif.
Afiliação
  • Prater AG; Department of BioSciences, Rice University, Houston, Texas, USA.
  • Mehta HH; Department of BioSciences, Rice University, Houston, Texas, USA.
  • Beabout K; Department of BioSciences, Rice University, Houston, Texas, USA.
  • Supandy A; Department of BioSciences, Rice University, Houston, Texas, USA.
  • Miller WR; Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, Texas, USA.
  • Tran TT; Center for Infectious Diseases, UTHealth School of Public Health, Houston, Texas, USA.
  • Arias CA; Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, Texas, USA.
  • Shamoo Y; Center for Infectious Diseases, UTHealth School of Public Health, Houston, Texas, USA.
Article em En | MEDLINE | ID: mdl-33468468
LiaFSR signaling plays a major role in mediating daptomycin (DAP) resistance in enterococci, and the lack of a functional LiaFSR pathway leads to DAP hypersusceptibility. Using in vitro experimental evolution, we evaluated how Enterococcus faecium with a liaR response regulator gene deletion evolved DAP resistance. We found that knocking out LiaFSR signaling significantly delayed the onset of resistance, but resistance could emerge eventually through various alternate mechanisms that were influenced by the environment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Bactérias Gram-Positivas / Enterococcus faecium / Daptomicina Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Bactérias Gram-Positivas / Enterococcus faecium / Daptomicina Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article