Your browser doesn't support javascript.
loading
Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii.
Cheng, Jiaqi; Yan, Jun; Reyna, Zeferino; Slarve, Matt; Lu, Peggy; Spellberg, Brad; Luna, Brian.
Afiliação
  • Cheng J; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
  • Yan J; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
  • Reyna Z; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
  • Slarve M; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
  • Lu P; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
  • Spellberg B; Los Angeles County-USC (LAC+USC) Medical Center, Los Angeles, California, USA.
  • Luna B; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA brian.luna@usc.edu.
Antimicrob Agents Chemother ; 65(4)2021 03 18.
Article em En | MEDLINE | ID: mdl-33468472
Recently, we reported rifabutin hyperactivity against Acinetobacter baumannii We sought to characterize potential interactions between rifabutin and colistin, the last-resort drug for carbapenem-resistant infections. Rifabutin and colistin were synergistic in vitro and in vivo, and low-dose colistin significantly suppressed emergence of resistance to rifabutin. Thus, this combination is a promising therapeutic option for highly resistant A. baumannii infections.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Acinetobacter / Acinetobacter baumannii Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Acinetobacter / Acinetobacter baumannii Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article