Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli.

El Zahed, Sara S; French, Shawn; Farha, Maya A; Kumar, Garima; Brown, Eric D

El Zahed, Sara S; French, Shawn; Farha, Maya A; Kumar, Garima; Brown, Eric D.

Afiliação

El Zahed SS; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
French S; Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Farha MA; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Kumar G; Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Brown ED; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Antimicrob Agents Chemother ; 65(4)2021 03 18.

Article em En | MEDLINE | ID: mdl-33468483

Assuntos

Antibacterianos; Escherichia coli; Antibacterianos/farmacologia; Transporte Biológico; Escherichia coli/genética

Palavras-chave

Gram-negative bacteria; efflux pumps; machine learning; molecular descriptors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escherichia coli / Antibacterianos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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