Astragaloside IV protects against podocyte apoptosis by inhibiting oxidative stress via activating PPARÎ³-Klotho-FoxO1 axis in diabetic nephropathy.

Xing, Lina; Fang, Ji; Zhu, Bingbing; Wang, Li; Chen, Junliang; Wang, Yunman; Huang, Jiebo; Wang, Hao; Yao, Xingmei

Xing, Lina; Fang, Ji; Zhu, Bingbing; Wang, Li; Chen, Junliang; Wang, Yunman; Huang, Jiebo; Wang, Hao; Yao, Xingmei.

Afiliação

Xing L; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Fang J; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Zhu B; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Wang L; Laboratory of Renal Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Chen J; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Wang Y; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Huang J; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Wang H; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China. Electronic address: wang402hao@163.com.
Yao X; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China. Electronic address: yaoxingmeiyxm@sina.com.

Life Sci ; 269: 119068, 2021 Mar 15.

Article em En | MEDLINE | ID: mdl-33476631

Assuntos

Apoptose; Nefropatias Diabéticas/prevenção & controle; Proteína Forkhead Box O1/metabolismo; Glucuronidase/metabolismo; PPAR gama/metabolismo; Podócitos/efeitos dos fármacos; Saponinas/farmacologia; Triterpenos/farmacologia; Animais; Diabetes Mellitus Experimental/complicações; Nefropatias Diabéticas/etiologia; Nefropatias Diabéticas/metabolismo; Nefropatias Diabéticas/patologia; Proteína Forkhead Box O1/genética; Regulação da Expressão Gênica; Glucose/metabolismo; Glucuronidase/genética; Proteínas Klotho; Masculino; Camundongos; Camundongos Endogâmicos C57BL; PPAR gama/genética; Podócitos/metabolismo; Podócitos/patologia; Substâncias Protetoras; Transdução de Sinais

Palavras-chave

Astragaloside IV; Diabetic nephropathy; FoxO1; Klotho; PPARÎ³; Podocyte apoptosis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saponinas / Triterpenos / Apoptose / PPAR gama / Nefropatias Diabéticas / Podócitos / Proteína Forkhead Box O1 / Glucuronidase Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google