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Developmental cell programs are co-opted in inflammatory skin disease.
Reynolds, Gary; Vegh, Peter; Fletcher, James; Poyner, Elizabeth F M; Stephenson, Emily; Goh, Issac; Botting, Rachel A; Huang, Ni; Olabi, Bayanne; Dubois, Anna; Dixon, David; Green, Kile; Maunder, Daniel; Engelbert, Justin; Efremova, Mirjana; Polanski, Krzysztof; Jardine, Laura; Jones, Claire; Ness, Thomas; Horsfall, Dave; McGrath, Jim; Carey, Christopher; Popescu, Dorin-Mirel; Webb, Simone; Wang, Xiao-Nong; Sayer, Ben; Park, Jong-Eun; Negri, Victor A; Belokhvostova, Daria; Lynch, Magnus D; McDonald, David; Filby, Andrew; Hagai, Tzachi; Meyer, Kerstin B; Husain, Akhtar; Coxhead, Jonathan; Vento-Tormo, Roser; Behjati, Sam; Lisgo, Steven; Villani, Alexandra-Chloé; Bacardit, Jaume; Jones, Philip H; O'Toole, Edel A; Ogg, Graham S; Rajan, Neil; Reynolds, Nick J; Teichmann, Sarah A; Watt, Fiona M; Haniffa, Muzlifah.
Afiliação
  • Reynolds G; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Vegh P; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Fletcher J; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Poyner EFM; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Stephenson E; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
  • Goh I; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Botting RA; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Huang N; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Olabi B; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Dubois A; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Dixon D; Department of Dermatology, NHS Lothian, Lauriston Building, Edinburgh EH3 9EN, UK.
  • Green K; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Maunder D; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
  • Engelbert J; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Efremova M; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Polanski K; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Jardine L; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Jones C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Ness T; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Horsfall D; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • McGrath J; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Carey C; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Popescu DM; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Webb S; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Wang XN; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Sayer B; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Park JE; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Negri VA; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Belokhvostova D; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Lynch MD; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • McDonald D; Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital Campus, London SE1 9RT, UK.
  • Filby A; Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital Campus, London SE1 9RT, UK.
  • Hagai T; Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital Campus, London SE1 9RT, UK.
  • Meyer KB; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Husain A; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Coxhead J; Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
  • Vento-Tormo R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Behjati S; Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
  • Lisgo S; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Villani AC; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Bacardit J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Jones PH; Department of Paediatrics, University of Cambridge, Cambridge CB2 0SP, UK.
  • O'Toole EA; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Ogg GS; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Rajan N; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.
  • Reynolds NJ; School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, UK.
  • Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Watt FM; MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK.
  • Haniffa M; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK.
Science ; 371(6527)2021 01 22.
Article em En | MEDLINE | ID: mdl-33479125
ABSTRACT
The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis. We leveraged these datasets to compare cell states across development, homeostasis, and disease. Our analysis revealed an enrichment of innate immune cells in skin during the first trimester and clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. We uncovered and validated in situ a reemergence of prenatal vascular endothelial cell and macrophage cellular programs in atopic dermatitis and psoriasis lesional skin. These data illustrate the dynamism of cutaneous immunity and provide opportunities for targeting pathological developmental programs in inflammatory skin diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Pele / Dermatite Atópica Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Pele / Dermatite Atópica Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article