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Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase.
Mahmood, Shams Ul; Cheng, Huimin; Tummalapalli, Sreedhar R; Chakrasali, Ramappa; Yadav Bheemanaboina, Rammohan R; Kreiss, Tamara; Chojnowski, Agnieska; Eck, Tyler; Siekierka, John J; Rotella, David P.
Afiliação
  • Mahmood SU; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
  • Cheng H; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
  • Tummalapalli SR; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
  • Chakrasali R; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
  • Yadav Bheemanaboina RR; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
  • Kreiss T; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
  • Chojnowski A; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
  • Eck T; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
  • Siekierka JJ; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
  • Rotella DP; Department of Chemistry and Biochemistry , Montclair State University , Montclair , NJ 07043 , USA . Email: rotellad@montclair.edu.
RSC Med Chem ; 11(1): 98-101, 2020 Jan 01.
Article em En | MEDLINE | ID: mdl-33479608
The cGMP-dependent protein kinase in Plasmodium falciparum (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in malaria models are not optimal. This communication describes initial optimization of a structurally distinct class of PfPKG inhibitors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article