To Degrade a MicroRNA, Destroy Its Argonaute Protein.

Wu, Pei-Hsuan; Zamore, Phillip D

Wu, Pei-Hsuan; Zamore, Phillip D.

Afiliação

Wu PH; Howard Hughes Medical Institute and RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: pei-hsuan.wu@umassmed.edu.
Zamore PD; Howard Hughes Medical Institute and RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: phillip.zamore@umassmed.edu.

Mol Cell ; 81(2): 223-225, 2021 01 21.

Article em En | MEDLINE | ID: mdl-33482091

ABSTRACT

ABSTRACT

Han et al. (2020) and Shi et al. (2020) report that the E3 ubiquitin ligase ZSWIM8 senses when an RNA and an Argonaute protein-bound microRNA are extensively base paired and directs Argonaute destruction by the proteasome. The result is degradation of the microRNA.

Assuntos

MicroRNAs; Ubiquitina; Proteínas Argonautas/genética; Proteínas Argonautas/metabolismo; MicroRNAs/genética; Complexo de Endopeptidases do Proteassoma/metabolismo; Ubiquitina/metabolismo; Ubiquitina-Proteína Ligases/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ubiquitina / MicroRNAs Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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