Breathing new life into the rational design of Alzheimer's therapeutics.
Cell
; 184(2): 296-298, 2021 01 21.
Article
em En
| MEDLINE
| ID: mdl-33482095
ABSTRACT
γ-secretase is a promising therapeutic target for Alzheimer's disease, but all inhibitors and modulators have failed due to toxicity or low efficacy. In this issue of Cell, Yang et al. provide cryo-EM structures of γ-secretase bound to three inhibitors and a modulator, giving new promise to targeting γ-secretase therapeutically.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article