Structural properties and in vitro and in vivo immunomodulatory activity of an arabinofuranan from the fruits of Akebia quinata.

Wang, Huimei; Wang, Xuelian; Li, Ying; Zhang, Shaojie; Li, Zhengguo; Li, Yuhao; Cui, Jianlin; Lan, Xiaozhong; Zhang, Erhao; Yuan, Lei; Jin, Da-Qing; Tuerhong, Muhetaer; Abudukeremu, Munira; Xu, Jing; Guo, Yuanqiang

Wang, Huimei; Wang, Xuelian; Li, Ying; Zhang, Shaojie; Li, Zhengguo; Li, Yuhao; Cui, Jianlin; Lan, Xiaozhong; Zhang, Erhao; Yuan, Lei; Jin, Da-Qing; Tuerhong, Muhetaer; Abudukeremu, Munira; Xu, Jing; Guo, Yuanqiang.

Afiliação

Wang H; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Wang X; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Li Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Zhang S; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Li Z; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Li Y; School of Medicine, Nankai University, Tianjin 300071, People's Republic of China.
Cui J; School of Medicine, Nankai University, Tianjin 300071, People's Republic of China.
Lan X; Food Science College, Tibet Agricultural & Animal Husbandry University, Linzhi 860000, People's Republic of China.
Zhang E; Food Science College, Tibet Agricultural & Animal Husbandry University, Linzhi 860000, People's Republic of China.
Yuan L; Food Science College, Tibet Agricultural & Animal Husbandry University, Linzhi 860000, People's Republic of China.
Jin DQ; School of Medicine, Nankai University, Tianjin 300071, People's Republic of China.
Tuerhong M; College of Chemistry and Environmental Sciences, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University, Kashgar 844000, People's Republic of China.
Abudukeremu M; College of Chemistry and Environmental Sciences, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University, Kashgar 844000, People's Republic of China.
Xu J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal Universit
Guo Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China. Electronic address: victgyq@nankai.edu.cn.

Carbohydr Polym ; 256: 117521, 2021 Mar 15.

Article em En | MEDLINE | ID: mdl-33483042

Assuntos

Frutas/química; Fatores Imunológicos/química; Polissacarídeos/química; Ranunculales/química; Espécies Reativas de Oxigênio/agonistas; Animais; Sequência de Carboidratos; Embrião não Mamífero; Fatores Imunológicos/isolamento & purificação; Fatores Imunológicos/farmacologia; Interleucina-1beta/imunologia; Interleucina-1beta/metabolismo; Interleucina-6/imunologia; Interleucina-6/metabolismo; Camundongos; Peso Molecular; Óxido Nítrico/imunologia; Óxido Nítrico/metabolismo; Fagocitose/efeitos dos fármacos; Extratos Vegetais/química; Polissacarídeos/isolamento & purificação; Polissacarídeos/farmacologia; Células RAW 264.7; Espécies Reativas de Oxigênio/imunologia; Espécies Reativas de Oxigênio/metabolismo; Estereoisomerismo; Fator de Necrose Tumoral alfa/imunologia; Fator de Necrose Tumoral alfa/metabolismo; Peixe-Zebra

Palavras-chave

Akebia quinata; Arabinofuranan; Immunoregulatory activity; Methyl iodide (PubChem CID: 6328); Neutral red (PubChem CID: 11105); O-tolylisothiocyanate (PubChem CID: 341280687); Pyridine (PubChem CID: 1049); RAW264.7 macrophage cells; Trifluoroacetic acid (PubChem CID: 6422); Zebrafish; d-Arabinose (PubChem CID: 854); d-Mannose (PubChem CID: 18950); l-Arabinose (PubChem CID: 439195); l-Fucose (PubChem CID: 17106); n-Butanol (PubChem CID: 341280687)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Espécies Reativas de Oxigênio / Ranunculales / Frutas / Fatores Imunológicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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