Factor Xa: Thrombokinase from Paul Morawitz to J Haskell Milstone.
J Thromb Thrombolysis
; 52(2): 364-370, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-33484373
ABSTRACT
In 1904 Paul Morawitz postulated that an enzyme, which he named thrombokinase, would be the primary activator of prothrombin. Fifty years passed before J Haskell Milstone isolated, purified and functionally characterized the enzyme we now call Factor Xa. This essay summarizes Milstone's work on thrombokinase, and finds context for why his efforts succeeded while others struggled.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protrombina
/
Fator Xa
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article