Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells.

Ascenção, Kelly; Dilek, Nahzli; Augsburger, Fiona; Panagaki, Theodora; Zuhra, Karim; Szabo, Csaba

Ascenção, Kelly; Dilek, Nahzli; Augsburger, Fiona; Panagaki, Theodora; Zuhra, Karim; Szabo, Csaba.

Afiliação

Ascenção K; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland. Electronic address: kelly.ascencao@unifr.ch.
Dilek N; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland. Electronic address: nahzli.dilek@unifr.ch.
Augsburger F; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland. Electronic address: fiona.augsburger@unifr.ch.
Panagaki T; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland. Electronic address: theodora.panagaki@unifr.ch.
Zuhra K; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland. Electronic address: karim.zuhra@unifr.ch.
Szabo C; Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland. Electronic address: csaba.szabo@unifr.ch.

Pharmacol Res ; 165: 105393, 2021 03.

Article em En | MEDLINE | ID: mdl-33484818

Assuntos

ATP Citrato (pro-S)-Liase/antagonistas & inibidores; Neoplasias do Colo/tratamento farmacológico; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Sulfeto de Hidrogênio/antagonistas & inibidores; ATP Citrato (pro-S)-Liase/metabolismo; Antineoplásicos/farmacologia; Western Blotting; Neoplasias do Colo/enzimologia; Neoplasias do Colo/metabolismo; Imunofluorescência; Células HCT116/efeitos dos fármacos; Células HCT116/enzimologia; Células HCT116/metabolismo; Humanos; Sulfeto de Hidrogênio/metabolismo; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Reação em Cadeia da Polimerase em Tempo Real

Palavras-chave

3-mercaptopyruvate sulfurtransferase; Colon cancer; Cystathionine-ß-synthase; Epithelial cells; Hydrogen sulfide; Mesenchymal cells; Nitric oxide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: ATP Citrato (pro-S)-Liase / Neoplasias do Colo / Transição Epitelial-Mesenquimal / Sulfeto de Hidrogênio Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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