The impact of technical failures on recombinant production of soluble proteins in Escherichia coli: a case study on process and protein robustness.

Pekarsky, Alexander; Reininger, Melanie; Spadiut, Oliver

Pekarsky, Alexander; Reininger, Melanie; Spadiut, Oliver.

Afiliação

Pekarsky A; Institute of Chemical, Environmental and Bioscience Engineering, Research Area Biochemical Engineering, Technische Universität Wien, TU Wien, Gumpendorferstrasse 1a, 1060, Vienna, Austria.
Reininger M; Institute of Chemical, Environmental and Bioscience Engineering, Research Area Biochemical Engineering, Technische Universität Wien, TU Wien, Gumpendorferstrasse 1a, 1060, Vienna, Austria.
Spadiut O; Institute of Chemical, Environmental and Bioscience Engineering, Research Area Biochemical Engineering, Technische Universität Wien, TU Wien, Gumpendorferstrasse 1a, 1060, Vienna, Austria. oliver.spadiut@tuwien.ac.at.

Bioprocess Biosyst Eng ; 44(6): 1049-1061, 2021 Jun.

Article em En | MEDLINE | ID: mdl-33491129

Assuntos

Escherichia coli/genética; Escherichia coli/metabolismo; Expressão Gênica; Proteínas Recombinantes/biossíntese; Proteínas Recombinantes/genética; Solubilidade

Palavras-chave

Bioreactor; Cytosolic protein; Escherichia coli; Process deviation; Protein glycation; Robustness

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Expressão Gênica / Escherichia coli Tipo de estudo: Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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