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Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo[3,2-c]quinolin-6-ones as Potent Topoisomerase-I Inhibitors.
Hsueh, Wen-Yun; Lee, Ying-Shuan E; Huang, Min-Sian; Lai, Chin-Hung; Gao, Yu-Sheng; Lin, Jo-Chu; Chen, Yu-Fen; Chang, Chih-Lin; Chou, Shan-Yen; Chen, Shyh-Fong; Lu, Yann-Yu; Chang, Lien-Hsiang; Lin, Shu Fu; Lin, Yu-Hsiang; Hsu, Pi-Chen; Wei, Win-Yin; Huang, Ya-Chi; Kao, Yi-Feng; Teng, Li-Wei; Liu, Hung-Huang; Chen, Ying-Chou; Yuan, Ta-Tung; Chan, Ya-Wen; Huang, Po-Hsun; Chao, Yu-Ting; Huang, Shin-Yi; Jian, Bo-Han; Huang, Hsin-Yi; Yang, Sheng-Chuan; Lo, Tzu-Hao; Huang, Guan-Ru; Wang, Shao-Yun; Lin, Her-Sheng; Chuang, Shih-Hsien; Huang, Jiann-Jyh.
Afiliação
  • Hsueh WY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Lee YE; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Huang MS; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Lai CH; Department of Applied Chemistry, Chung Shan Medical University, Taichung 40201, Taiwan.
  • Gao YS; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Lin JC; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Chen YF; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Chang CL; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Chou SY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Chen SF; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Lu YY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Chang LH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Lin SF; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Lin YH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Hsu PC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Wei WY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Huang YC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Kao YF; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Teng LW; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Liu HH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Chen YC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Yuan TT; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Chan YW; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Huang PH; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Chao YT; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Huang SY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Jian BH; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Huang HY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Yang SC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Lo TH; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Huang GR; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Wang SY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
  • Lin HS; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Chuang SH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
  • Huang JJ; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
J Med Chem ; 64(3): 1435-1453, 2021 02 11.
Article em En | MEDLINE | ID: mdl-33492141
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas / Cobre / Inibidores da Topoisomerase I / Antineoplásicos / Nitrilas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas / Cobre / Inibidores da Topoisomerase I / Antineoplásicos / Nitrilas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article