Deleting <i>Mecp2</i> from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice.

Achilly, Nathan P; He, Ling-Jie; Kim, Olivia A; Ohmae, Shogo; Wojaczynski, Gregory J; Lin, Tao; Sillitoe, Roy V; Medina, Javier F; Zoghbi, Huda Y

Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice.

Achilly, Nathan P; He, Ling-Jie; Kim, Olivia A; Ohmae, Shogo; Wojaczynski, Gregory J; Lin, Tao; Sillitoe, Roy V; Medina, Javier F; Zoghbi, Huda Y.

Afiliação

Achilly NP; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.
He LJ; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.
Kim OA; Medical Scientist Training Program, Baylor College of Medicine, Houston, United States.
Ohmae S; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.
Wojaczynski GJ; Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, United States.
Lin T; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, United States.
Sillitoe RV; Department of Neuroscience, Baylor College of Medicine, Houston, United States.
Medina JF; Department of Neuroscience, Baylor College of Medicine, Houston, United States.
Zoghbi HY; Department of Neuroscience, Baylor College of Medicine, Houston, United States.

Elife ; 102021 01 26.

Article em En | MEDLINE | ID: mdl-33494858

Assuntos

Cerebelo/química; Deleção de Genes; Aprendizagem; Proteína 2 de Ligação a Metil-CpG/genética; Atividade Motora/genética; Neurônios/química; Síndrome de Rett/genética; Animais; Modelos Animais de Doenças; Humanos; Masculino; Proteína 2 de Ligação a Metil-CpG/deficiência; Camundongos; Camundongos Knockout; Fatores de Tempo

Palavras-chave

MeCP2; Rett syndrome; cerebellum; motor learning; mouse; neuroscience

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Rett / Cerebelo / Deleção de Genes / Proteína 2 de Ligação a Metil-CpG / Aprendizagem / Atividade Motora / Neurônios Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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