Replication-Coupled Chromatin Remodeling: An Overview of Disassembly and Assembly of Chromatin during Replication.
Int J Mol Sci
; 22(3)2021 Jan 23.
Article
em En
| MEDLINE
| ID: mdl-33498649
ABSTRACT
The doubling of genomic DNA during the S-phase of the cell cycle involves the global remodeling of chromatin at replication forks. The present review focuses on the eviction of nucleosomes in front of the replication forks to facilitate the passage of replication machinery and the mechanism of replication-coupled chromatin assembly behind the replication forks. The recycling of parental histones as well as the nuclear import and the assembly of newly synthesized histones are also discussed with regard to the epigenetic inheritance.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
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Nucleossomos
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Montagem e Desmontagem da Cromatina
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Epigênese Genética
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Replicação do DNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article