No change in neurodevelopment at 11 years after extremely preterm birth.
Arch Dis Child Fetal Neonatal Ed
; 106(4): 418-424, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-33504573
ABSTRACT
OBJECTIVE:
To determine whether improvements in school age outcomes had occurred between two cohorts of births at 22-25 weeks of gestation to women residents in England in 1995 and 2006.DESIGN:
Longitudinal national cohort studies.SETTING:
School-based or home-based assessments at 11 years of age.PARTICIPANTS:
EPICure2 cohort of births at 22-26 weeks of gestation in England during 2006 a sample of 200 of 1031 survivors were evaluated; outcomes for 112 children born at 22-25 weeks of gestation were compared with those of 176 born in England during 1995 from the EPICure cohort. Classroom controls for each group acted as a reference population. MAIN OUTCOMEMEASURES:
Standardised measures of cognition and academic attainment were combined with parent report of other impairments to estimate overall neurodevelopmental status.RESULTS:
At 11 years in EPICure2, 18% had severe and 20% moderate impairments. Comparing births at 22-25 weeks in EPICure2 (n=112), 26% had severe and 21% moderate impairment compared with 18% and 32%, respectively, in EPICure. After adjustment, the OR of moderate or severe neurodevelopmental impairment in 2006 compared with 1995 was 0.76 (95% CI 0.45 to 1.31, p=0.32). IQ scores were similar in 1995 (mean 82.7, SD 18.4) and 2006 (81.4, SD 19.2), adjusted difference in mean z-scores 0.2 SD (95% CI -0.2 to 0.6), as were attainment test scores. The use of multiple imputation did not alter these findings.CONCLUSION:
Improvements in care and survival between 1995 and 2006 are not paralleled by improved cognitive or educational outcomes or a reduced rate of neurodevelopmental impairment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lactente Extremamente Prematuro
/
Transtornos do Neurodesenvolvimento
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
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Infant
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Male
/
Newborn
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article