Inhibition of hepatocyte nuclear factor 1ß contributes to cisplatin nephrotoxicity via regulation of nf-&#954;b pathway.

Zhang, Yan; Hao, Jielu; Du, Zijun; Li, Peiyao; Hu, Jinghua; Ruan, Mengna; Li, Shulian; Ma, Yuanfang; Lou, Qiang

Inhibition of hepatocyte nuclear factor 1ß contributes to cisplatin nephrotoxicity via regulation of nf-κb pathway.

Zhang, Yan; Hao, Jielu; Du, Zijun; Li, Peiyao; Hu, Jinghua; Ruan, Mengna; Li, Shulian; Ma, Yuanfang; Lou, Qiang.

Afiliação

Zhang Y; Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China.
Hao J; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Du Z; Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China.
Li P; Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China.
Hu J; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Ruan M; Department of Nephrology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Li S; Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China.
Ma Y; Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China.
Lou Q; Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China.

J Cell Mol Med ; 25(6): 2861-2871, 2021 03.

Article em En | MEDLINE | ID: mdl-33512774

Assuntos

Antineoplásicos/efeitos adversos; Cisplatino/efeitos adversos; Fator 1-beta Nuclear de Hepatócito/genética; NF-kappa B/metabolismo; Néfrons/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Injúria Renal Aguda/etiologia; Injúria Renal Aguda/metabolismo; Animais; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Cisplatino/farmacologia; Modelos Animais de Doenças; Fator 1-beta Nuclear de Hepatócito/metabolismo; Túbulos Renais/efeitos dos fármacos; Camundongos; Camundongos Knockout; Fosforilação/efeitos dos fármacos; Ratos; Fator de Transcrição RelA/metabolismo

Palavras-chave

Hepatocyte nuclear factor 1ß; NF-κB; cisplatin nephrotoxicity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / NF-kappa B / Cisplatino / Fator 1-beta Nuclear de Hepatócito / Néfrons / Antineoplásicos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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