Allostery governs Cdk2 activation and differential recognition of CDK inhibitors.

Majumdar, Abir; Burban, David J; Muretta, Joseph M; Thompson, Andrew R; Engel, Tiffany A; Rasmussen, Damien M; Subrahmanian, Manu V; Veglia, Gianluigi; Thomas, David D; Levinson, Nicholas M

Majumdar, Abir; Burban, David J; Muretta, Joseph M; Thompson, Andrew R; Engel, Tiffany A; Rasmussen, Damien M; Subrahmanian, Manu V; Veglia, Gianluigi; Thomas, David D; Levinson, Nicholas M.

Afiliação

Majumdar A; Department of Pharmacology and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Burban DJ; Department of Pharmacology and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Muretta JM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Thompson AR; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Engel TA; Department of Pharmacology and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Rasmussen DM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Subrahmanian MV; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Veglia G; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Thomas DD; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Levinson NM; Department of Pharmacology and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA. nml@umn.edu.

Nat Chem Biol ; 17(4): 456-464, 2021 04.

Article em En | MEDLINE | ID: mdl-33526892

Assuntos

Regulação Alostérica/fisiologia; Quinase 2 Dependente de Ciclina/metabolismo; Sítio Alostérico/genética; Ciclo Celular/fisiologia; Proteínas de Ciclo Celular/metabolismo; Ciclina A/metabolismo; Quinase 2 Dependente de Ciclina/antagonistas & inibidores; Quinases Ciclina-Dependentes/antagonistas & inibidores; Quinases Ciclina-Dependentes/metabolismo; Ciclinas/metabolismo; Humanos; Proteínas Associadas aos Microtúbulos/metabolismo; Modelos Biológicos; Fosforilação/fisiologia; Inibidores de Proteínas Quinases/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas/metabolismo; Proteínas Supressoras de Tumor/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Alostérica / Quinase 2 Dependente de Ciclina Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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