Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway.

Dong, Xiaobo; Wang, Lei; Song, Guangrong; Cai, Xu; Wang, Wenxin; Chen, Jiaqi; Wang, Gesheng

Dong, Xiaobo; Wang, Lei; Song, Guangrong; Cai, Xu; Wang, Wenxin; Chen, Jiaqi; Wang, Gesheng.

Afiliação

Dong X; The Third Department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, People's Republic of China.
Wang L; The Third Department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, People's Republic of China.
Song G; The Third Department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, People's Republic of China.
Cai X; The Third Department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, People's Republic of China.
Wang W; The Third Department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, People's Republic of China.
Chen J; The Third Department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, People's Republic of China.
Wang G; The Third Department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, People's Republic of China.

Drug Des Devel Ther ; 15: 277-287, 2021.

Article em En | MEDLINE | ID: mdl-33536742

Assuntos

Isquemia Encefálica/tratamento farmacológico; Emodina/análogos & derivados; Substâncias Protetoras/farmacologia; Traumatismo por Reperfusão/tratamento farmacológico; Animais; Isquemia Encefálica/metabolismo; Linhagem Celular Tumoral; Emodina/farmacologia; Humanos; NF-kappa B/antagonistas & inibidores; NF-kappa B/metabolismo; Ratos; Ratos Sprague-Dawley; Traumatismo por Reperfusão/metabolismo; Traumatismo por Reperfusão/patologia; Transdução de Sinais/efeitos dos fármacos; Receptor 4 Toll-Like/antagonistas & inibidores; Receptor 4 Toll-Like/metabolismo

Palavras-chave

NF-κB; ischemia-reperfusion injury; physcion; stroke

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Isquemia Encefálica / Emodina / Substâncias Protetoras Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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