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N-glycan-mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP.
Ercig, Bogac; Graça, Nuno A G; Kangro, Kadri; Arfman, Tom; Wichapong, Kanin; Hrdinová, Johana; Kaijen, Paul; van Alphen, Floris P J; van den Biggelaar, Maartje; Vanhoorelbeke, Karen; Veyradier, Agnès; Coppo, Paul; Reutelingsperger, Chris; Nicolaes, Gerry A F; Männik, Andres; Voorberg, Jan.
Afiliação
  • Ercig B; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
  • Graça NAG; PharmaTarget BV, Maastricht, The Netherlands.
  • Kangro K; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
  • Arfman T; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
  • Wichapong K; Icosagen Cell Factory OÜ, Kambja vald, Tartumaa, Estonia.
  • Hrdinová J; Icosagen Cell Factory OÜ, Kambja vald, Tartumaa, Estonia.
  • Kaijen P; Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
  • van Alphen FPJ; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
  • van den Biggelaar M; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
  • Vanhoorelbeke K; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
  • Veyradier A; PharmaTarget BV, Maastricht, The Netherlands.
  • Coppo P; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
  • Reutelingsperger C; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
  • Nicolaes GAF; Research Facilities, Sanquin, Amsterdam, The Netherlands.
  • Männik A; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
  • Voorberg J; Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
Blood ; 137(19): 2694-2698, 2021 05 13.
Article em En | MEDLINE | ID: mdl-33544829
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Púrpura Trombocitopênica Trombótica / Autoanticorpos / Autoantígenos / Proteína ADAMTS13 / Complexo Antígeno-Anticorpo / Reações Antígeno-Anticorpo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Púrpura Trombocitopênica Trombótica / Autoanticorpos / Autoantígenos / Proteína ADAMTS13 / Complexo Antígeno-Anticorpo / Reações Antígeno-Anticorpo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article